Exercise on GLP-1: Workouts & Performance Protocol

Published January 11, 2026 | Fitness Guide | 10 min read

Exercise accelerates weight loss 20-30% on GLP-1. But timing, intensity, and nutrition matter critically. This guide shows the evidence-based approach used by our Lagos fitness clients.

The Timeline: When to Start Training

Weeks 1-2: REST ONLY (No Exercise)

Your body is adjusting to appetite suppression. Energy is lower. Side effects (nausea, fatigue) peak. Intense exercise = dangerous. Only activity: light 15-20 minute walks on days 3-5.

Weeks 3-4: Walking Phase

Appetite settling. Nausea fading. Energy returning. Start regular walking: 20-30 minutes daily, moderate pace (conversation pace). No strength training yet. Walking burns calories without depleting glycogen stores.

Weeks 5+: Full Exercise Introduction

Side effects mostly gone. Appetite suppression stable. Energy normal. Now introduce structured strength + cardio. Phase approach below.

Why wait 4 weeks? Premature intense exercise on GLP-1 causes: severe nausea, fainting, dehydration. Your muscles need energy. GLP-1 reduces it. Give 4 weeks adaptation.

Phase 1 Exercise (Weeks 5-8): Foundation Building

Goal: Build habit, create calorie deficit, preserve muscle base

Frequency: 3-4 days/week

Structure: Strength training focus (body prefers preserving strength).

Workout A: Lower Body (Monday & Thursday)

• Bodyweight squats: 3x 15 reps

• Lunges: 3x 10 each leg

• Calf raises: 3x 20

• Glute bridges: 3x 15

Duration: 30 minutes | Intensity: moderate | Rest 90 seconds between sets

Workout B: Upper Body (Tuesday & Friday)

• Push-ups: 3x 8-12 reps (or incline if needed)

• Rows (band or machine): 3x 12

• Dumbbell press: 3x 10

• Planks: 3x 30-45 seconds

Duration: 30 minutes | Intensity: moderate | Rest 90 seconds between sets

Cardio (Wednesday & Optional Weekend)

• Walking: 30-45 minutes OR light jogging: 20-30 minutes

• Keep heart rate 120-140 bpm (conversational pace)

• Duration: 30-45 minutes | Intensity: Low-moderate

Calorie burn estimate: 300-450 kcal total daily activity. Synergizes with appetite suppression for 1.0-1.2 kg/week loss.

Phase 2 Exercise (Weeks 9-16): Performance Building

Goal: Increase intensity, maintain muscle, accelerate weight loss

Frequency: 4-5 days/week

Progression: Add weights. Increase reps. Higher intensity cardio.

Workout A: Lower Body + Core (Monday & Thursday)

• Goblet squats: 4x 12 (5-8kg weight)

• Walking lunges: 3x 12 each leg

• Deadlifts (light): 3x 8 (10-15kg)

• Planks: 3x 60 seconds

• Russian twists: 3x 15 each side

Duration: 40 minutes | Rest: 60 seconds between sets

Workout B: Upper Body (Tuesday & Friday)

• Dumbbell bench press: 4x 10

• Bent rows: 4x 12

• Shoulder press: 3x 10

• Bicep curls: 3x 12

• Tricep dips: 3x 10

Duration: 40 minutes | Rest: 60 seconds between sets

Cardio (Wednesday, Saturday)

• Option 1: Running 30-40 minutes (steady pace)

• Option 2: Interval training 25-30 min (3 min easy, 2 min moderate, repeat 5x)

• Cycling 40-50 minutes steady

Duration: 30-50 minutes | Intensity: Moderate-High

Calorie burn estimate: 500-700 kcal daily. Combined with GLP-1 = 1.2-1.5 kg/week loss.

Phase 3 Exercise (Weeks 17+): Maintenance & Optimization

Goal: Maintain muscle, optimize performance, reach target weight

Frequency: 5-6 days/week

Structure: Advanced strength + performance cardio

Key Exercise Principles on GLP-1

Principle 1: Prioritize Strength Over Cardio

Cardio burns calories but muscle training preserves lean mass. On GLP-1, you want:

Principle 2: Eat Protein Post-Workout

Within 2 hours after strength training, consume 30-40g protein. Muscles need it for recovery. Appetite suppression might limit intake - use protein shake if needed.

Principle 3: Stay Hydrated During Exercise

GLP-1 causes dehydration risk. Drink 500-750mL water during workout. Don't wait until thirsty - thirst signal is suppressed.

Principle 4: Avoid Overtraining

Calorie deficit + exercise = recovery stress. Limit intense workouts to 3-4/week. Too much = fatigue, injury, weight loss plateau.

Exercise Mistakes to Avoid

Mistake 1: Starting intense exercise week 1-2 → Nausea/fainting risk. Wait until week 5 minimum.

Mistake 2: Doing only cardio → Lose muscle along with fat. Bad body composition. Add strength training.

Mistake 3: Not eating enough post-workout → Recovery impaired. Muscle breakdown. Worse results. Eat protein after training.

Mistake 4: Skipping rest days → Burnout. Injury. Illness. Muscle grows on rest, not training. Rest is critical.

Lagos Gym Recommendations

Equipment needed: Dumbbells (5-20kg), barbells, benches, pull-up bar. Any proper gym has these. Boutique CrossFit boxes also good for community/accountability.

Home workout alternative: If gym access is limited, bodyweight + resistance bands can cover most movements. Resistance bands are widely available online and in sports stores.

Popular Lagos gyms optimized for weight loss clients:

Tracking Exercise Progress

Record these weekly:

Special Scenarios

If Fatigued During Workout

Stop. Go home. Eat carbs + protein. Fatigue signals underfueling. Your body needs calories. GLP-1 suppresses hunger, not actual need for fuel. Eat more.

If Severe Muscle Soreness Lasts 5+ Days

You overdid it. Take 2-3 rest days. Increase protein to 150g daily. Next workout: 50% intensity. Build back slowly.

If Scale Stops Moving But Measurements Decrease

Normal. You're losing fat, gaining muscle from exercise. Scale doesn't show this. Waist circumference is better metric. This is actually better body composition.

If Injured During Workout

Stop that exercise. Rest 3-5 days. Do other muscle groups. Weight loss doesn't stop just because you can't train one area.

Performance Expectations Timeline

When to Seek Help

Contact a trainer if:

EkoPeptide can recommend Lagos personal trainers experienced with GLP-1 clients (different approach than normal training).

Related Articles:

Nutrition Guide for Weight Loss Tracking Exercise Performance Side Effects Management During Exercise
GET PERSONALIZED WORKOUT PLAN

Lagos trainers create GLP-1-optimized programs • Pair with nutrition + medical oversight

References

  1. Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). N Engl J Med. 2021.
  2. Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022.

Medically Reviewed by Dr. Chukwuemeka Okonkwo

MBBS, FMCP - Endocrinology

Content reviewed by qualified healthcare professionals for accuracy.