GLP-1 Frequently Asked Questions
Top questions from our Lagos patients. Evidence-based answers.
Safety & Side Effects
Q: Is GLP-1 safe long-term?
A: Yes. Used safely for 20+ years in diabetes patients. Millions globally. Side effects decrease over time. Most concern about "off-label" use for weight loss only - but same drug, same safety profile.
Q: Will I regain weight when I stop?
A: 70% of people do regain 50% of weight without medication. That's why most stay on maintenance dose indefinitely. It's not about "addiction" - it's how your body is wired. Like blood pressure medication: you stop, pressure returns.
Q: Can GLP-1 cause cancer?
A: No. FDA reviewed this extensively. Black box warning is theoretical risk in rare thyroid cancer cases (family history). Screening catches this. No human cases of GLP-1 causing cancer in 20-year history.
Q: Is Tirzepatide safe? It's new.
A: Approved 2022. Millions users now. Safety profile excellent. "New" doesn't mean risky - just newer data. Same regulatory approval as Semaglutide.
Usage & Results
Q: When do I see results?
A: Weight loss starts week 3-4 (1-2 kg). Clothes fit different by week 6-8. People comment by week 8-12. Expecting week 1 results = setup for disappointment.
Q: How much weight will I lose?
A: Average 10-15 kg in 6 months (Semaglutide), 15-20 kg (Tirzepatide). Depends: starting weight, exercise, nutrition, genetics. No guarantee - but data is solid.
Q: Do I need exercise?
A: No, but you should. GLP-1 alone = weight loss. GLP-1 + exercise = faster loss + better body composition + preserved muscle. Don't skip it.
Q: Can I drink alcohol on GLP-1?
A: Technically yes. Practically: GLP-1 + alcohol = increased intoxication + more nausea. First 4 weeks: skip. After: limit to 1-2 drinks weekly with food.
Safety & Access
Q: Do I need medical supervision?
A: Yes. EkoPeptide requires initial screening labs + monthly check-ins. This isn't optional - it's safety. Black market GLP-1 = dangerous (no dosing guidance, no monitoring).
Practical Questions
Q: How do I inject myself?
A: Subcutaneous injection (under skin) in abdomen/thigh. Needle is tiny (31-gauge). Looks scary, feels like gentle pinch. We video train you. Most people find it easy after first injection.
Q: Where do I store it?
A: Refrigerated (2-8°C) in original packaging. Keep needle in cool bag during travel. Room temperature = degrades. Pharmacy temp bags provided with delivery.
Q: What if I miss a dose?
A: Take when you remember (if <2 days late). If late >2 days, skip that dose, resume next scheduled day. Don't double up.
Q: Can I travel with GLP-1?
A: Yes. Keep in cool bag. Flying within Nigeria = fine. International = check destination country laws (some restrict GLP-1 imports). EkoPeptide can advise specific countries.
Medical Interactions
Q: I'm on diabetes medication. Can I use GLP-1?
A: Yes. But other diabetes meds may need dose reduction (risk of low blood sugar). Doctor monitors and adjusts. Very common scenario.
Q: I'm on blood pressure medication. Will GLP-1 interact?
A: No direct interaction. But GLP-1 often lowers blood pressure. Your BP med dose may need reduction. Doctor monitors BP and adjusts medications.
Q: Can I use GLP-1 if I have thyroid disease?
A: Hypothyroidism (most common) = fine. TSH monitoring recommended. Hyperthyroidism = generally ok but monitor. Thyroid cancer history = contraindicated.
Lifestyle Questions
Q: Will I be able to eat normally again?
A: Yes, but your "normal" shifts. Most people stay on maintenance dose to keep appetite suppressed. Without medication, appetite returns to baseline. You choose maintenance or accept regain.
Q: Can I eat my favorite foods?
A: Yes. GLP-1 suppresses portion size, not food type. You can have junk food - but appetite suppression means you eat less, so less damage. Doesn't mean healthy eating not important.
Q: Will I have energy for work?
A: Week 1-2 = slightly lower energy (normal). By week 3-4 = energy returns. Most people report feeling MORE energetic at lower weight. Lagos professionals do this successfully while working full-time.
Outcome Questions
Q: What if I don't lose 15kg in 3 months?
A: Individual variation is normal. If <1 kg/month after 8 weeks, protocol adjustment needed: escalate dose, improve nutrition, add exercise, or investigate medical issues. Not a failure.
Q: Can I stop anytime?
A: Yes. Completely reversible. No withdrawal. But expect appetite return + weight regain (70% of lost weight, typically). Stopping is medical decision, not emergency.
Q: Will excess skin be a problem?
A: If losing 30+ kg, some loose skin likely. Decreases with time, exercise, hydration. Rarely requires surgery. Slow loss (over 1 year) = less excess skin than crash dieting.
Q: Is muscle loss inevitable?
A: Some (15-30% of loss is lean mass typical). Minimize with: high protein (120+ g/day), strength training 3-4x/week. Tirzepatide preserves more muscle than Semaglutide.
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References
Medically Reviewed by Dr. Chukwuemeka Okonkwo
MBBS, FMCP - Endocrinology
Content reviewed by qualified healthcare professionals for accuracy.