Preparation Checklist

Before your first injection, ensure you have:

Semaglutide (vial or pre-filled pen)
Insulin syringes (if using vials) - 30 or 31 gauge, 1/2 inch
Alcohol wipes
Sharps disposal container
Clean, flat surface to work on

PRO TIP

Remove medication from refrigerator 15-30 minutes before injection. Room temperature medication causes less discomfort than cold medication.

Step-by-Step Injection Process

1. WASH HANDS

Thoroughly with soap and water, at least 20 seconds. Dry completely.

2. INSPECT MEDICATION

Should be clear, colorless, and free of particles. Don't use if cloudy or discolored.

3. CHOOSE INJECTION SITE

Options:

Abdomen (2 inches from belly button) - most common
Front of thigh
Back of upper arm

Rotate sites weekly to prevent lipodystrophy.

4. CLEAN INJECTION SITE

Wipe with alcohol in circular motion. Allow to air dry completely (30+ seconds).

5. DRAW MEDICATION (IF USING VIAL)

Clean vial rubber stopper with alcohol. Draw prescribed dose into syringe. Tap to remove air bubbles.

6. INJECT

Pinch skin gently. Insert needle at 90-degree angle (45 degrees if very lean). Push plunger slowly and steadily. Hold for 10 seconds before withdrawing.

7. DISPOSE SAFELY

Place needle directly in sharps container. Never recap, bend, or throw in regular trash.

Weekly Injection Schedule

Semaglutide is a once-weekly injection. Choose the same day each week for consistency. If you miss a dose:

Within 5 days: Take the missed dose as soon as you remember
More than 5 days: Skip the missed dose and take your next dose on the regular day
Never double up: Don't take two doses at once

Common Questions

Does it hurt?
Most people describe it as a mild pinch. The needles are very thin (30-31 gauge). After a few weeks, you'll barely notice.

What time of day is best?
There's no medical reason to prefer morning or evening. Many users choose evening so any initial nausea occurs during sleep.

Can I inject through clothing?
No. Always inject on clean, bare skin.

What if I see blood?
Minor bleeding is normal and harmless. Apply gentle pressure with a cotton ball.

How to Inject Semaglutide